Breast Cancer Treatment Options
Does Radiation Therapy Improve Survival for Women with Ductal Carcinoma in Situ?
Approximately 60,000 patients in the United States will receive a diagnosis of ductal carcinoma in situ (DCIS) in 2016. DCIS is not an invasive form of cancer and the 10-year survival rate for women with DCIS is greater than 98 percent. However, incidence of DCIS has increased dramatically over the last three decades, and being able to determine which women are among the small percentage at higher risk of breast cancer recurrence and mortality could help clinicians and patients tailor treatment to neither overtreat nor undertreat the disease.
Investigators from Brigham and Women’s Hospital (BWH) and the Dana-Farber Cancer Institute have found that a set of easily measurable risk factors can predict the magnitude of survival benefit offered by radiation therapy following breast cancer surgery. Their results appear online in the Journal of Clinical Oncology on Feb. 1.
A release from BWH quotes co-senior author Mehra Golshan, MD, Al-Tuwaijri Family Distinguished Chair of Surgical Oncology at Dana-Farber/Brigham and Women’s Cancer Center, as saying, “DCIS has a very low breast cancer mortality, which means that as an oncology community, we must be cognizant of overtreatment. Radiation therapy after breast cancer surgery has become a widely accepted treatment option for patients undergoing breast conserving therapy (or lumpectomy) with DCIS. Our results provide information that can guide individual treatment options, and better predict survival benefit from radiation therapy based on an individual’s case.”
For their retrospective, longitudinal study, Golshan and colleagues examined data from more than 32,000 patients treated for DCIS, including more than 20,000 who received radiation therapy and breast cancer surgery and more than 11,000 who received breast cancer surgery alone. Breast cancer mortality rates at 10 years were low for both groups: 1.8 percent for the group that received radiation therapy and 2.1 percent for the group that did not.
The team then assigned each patient a validated prognostic score on a scale of zero to six based on a set of three risk factors: nuclear grade (a measure of how abnormal cells look under a microscope); patient’s age; and tumor size. Patients with a higher nuclear grade, younger age and/or larger DCIS received a higher score; those with a lower nuclear grade, older age and/or smaller DCIS received a lower score. Past studies have shown that a patient’s prognostic score can predict breast cancer recurrence, but such scores had not previously been used to assess the effectiveness of treatment decisions on long term breast cancer survival.