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Medical Research
Women's Health

Females Ignored in Medical Research

Research done at Northwestern Medicine in Chicago has found that surgical researchers rarely use female animals or female cells in the research for their published studies, despite a huge body of evidence showing that gender differences can play a crucial role in medical research. The study was published August 28th 2014 in the journal Surgery. A “60 Minutes” segment aired in February about the problem of overlooking sex differences in biomedical research featuring Northwestern Medicine scientists Melina Kibbe M.D. and Teresa Woodruff.

As a result, editors of the five major surgical journals reviewed in this study have responded to this finding and will now require authors to state the sex of animals and cells used in their studies. If they use only one sex in their studies, they will be asked to justify why.

A release from the university quotes Dr. Kibbe, senior author of the study and a vascular surgeon at Northwestern Medicine, as saying, “Women make up half the population, but in surgical literature, 80 percent of the studies only use males. We need to do better and provide basic research on both sexes to ultimately improve treatments for male and female patients.”

The release notes that basic science research has shown repeatedly that male and female animals metabolize drugs differently. Accordingly, the research shows that men and women may experience differences in the ways they manifest diseases, experience illnesses and benefit from treatments.

“Requiring the sex of animals and cells is a very small thing to ask of authors,” Kibbe said. “It should be a requirement of all medical journals.”

Kibbe is a member of the Women’s Health Research Institute and is the Edward G. Elcock Professor of Surgical Research at Northwestern University Feinberg School of Medicine.

For the paper, 2,347 studies from Annals of Surgery, American Journal of Surgery, JAMA Surgery, Journal of Surgical Research, and Surgery from 2011 to 2012 were reviewed. Just over 600 of those articles included animal or cell research.

More highlights from the study:

• 22 percent of publications using animals did not state the sex studied.

• In studies that stated the sex of the animal, 80 percent used male animals, 17 percent used females and three percent used both.

• Most of the studies using cell research did not specify the sex (76 percent).

• In cell research that did specify the sex, 71 percent used only male cells, 21 percent only female cells and seven percent used cells from both sexes.

• Only one percent of studies reported sex-based results.In female-prevalent diseases, 44 percent did not report the sex; when reported, only 14 percent studied females.

A few years ago, Kibbe was encouraged to include female rats in her vascular research by fellow Northwestern scientist Teresa Woodruff. Like many researchers, Kibbe only used males because they were “easier” to study since they lacked the hormonal changes of female rats.

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