Helping Spinal Cord Patients Breathe on Their Own

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Diaphragm pacing, a system that gained nationwide attention when Raymond Onders, MD of University Hospitals Case Medical Center in Clevelandimplanted the stimulator in actor Christopher Reeve, has now been shown to be successful not only in weaning patients from mechanical ventilators but also in bridging patients to independent respiration. The study, done at the center, was published in the Journal of Trauma and Acute Care Surgery.

A release from the center explains that the Diaphragm Pacing System (DPS) provides electrical stimulation to nerves running through the diaphragm, the major muscle involved in breathing. When stimulated, the diaphragm contracts and allows patients to breathe more naturally than if air were forced into their lungs via a mechanical ventilator. The system is implanted through minimally invasive laparoscopic surgery.

The new study examined the records of 29 patients at 16 hospitals in the United States where DP implantation is approved. SCIs were caused by a variety of accidents, including car accidents, diving, gunshot wounds, falls, and athletic injuries. Elapsed time from injury to surgery was 40 days, which was considerably shorter than an initial FDA trial in which patients did not have DP testing and surgery for more than a year after injury. All but two patients were men. A goal of this study was to determine if earlier testing and DP implants provided benefit.

Of the patients whose diaphragm muscles responded to stimulation, 16 of 22 patients (72 percent) were completely free of ventilator support in an average of 10 days. Of the remaining six patients, two had a delayed weaning of six months, three had partial weans using DP at times during the day. One patient successfully implanted went to a long-term acute care hospital and subsequently had life-prolonging measures withdrawn. Seven of the 29 patients were found to have non-stimulatable diaphragms because of nerve damage. Eight patients (36 percent) had complete recovery of respiration, and DP wires were removed.

The release quotes Dr. Onders as saying, "This study provides several important observations. Most notably, laparoscopic diaphragm mapping – an electronic reading of the diaphragm nerves – is safe and can be performed in multiple centers with success. In addition, early diaphragm mapping can quickly determine if a phrenic nerve injury is complete, allowing for early ventilator planning and prevention of weaning trials if we find the patient will not be able to be weaned from the ventilator. Finally, DP can successfully wean traumatic cervical SCI patients as evidenced by 72 percent of the implanted patients being completely weaned from ventilators and 36 percent with complete recovery and DP removal. DP is a major step in improving the quality of life for patients who have spinal cord injuries and cannot breathe without the help of a ventilator. Based on testimonials that I've received from patients who have been in the clinical trials, DP provides patients with a freedom of mobility that they never imagined. They've sent photographs or videos themselves parachuting from planes, sailing solo, or enjoying rides at amusement parks with their families; activities impossible to do with a ventilator."

Traumatic spinal cord injuries (SCIs) that require chronic ventilator dependence are relatively rare: Less than four percent or 480 cases out of the estimated 12,000 traumatic SCIs occurring annually in the United States.

DPS has also been approved for patients with amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig's disease) and is being used in patients with other conditions as well.

DPS is made by Synapse Biomedical, Inc., a company co-founded by Dr. Onders and located in Oberlin, Ohio. Dr. Onders, UH Case Medical Center, and Case Western Reserve University have intellectual property rights in Synapse.