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Hearing Loss

A Likely New Contributor to Age-Related Hearing Loss

Conventional wisdom has long blamed age-related hearing loss almost entirely on the death of sensory hair cells in the inner ear, but research from neuroscientists at Johns Hopkins has provided new information about the workings of nerve cells that suggests otherwise.

In a paper published July 1 2015 in The Journal of Neuroscience, the Johns Hopkins team says its studies in mice have verified an increased number of connections between certain sensory cells and nerve cells in the inner ear of aging mice. Because these connections normally tamp down hearing when an animal is exposed to loud sound, the scientists think these new connections could also be contributing to age-related hearing loss in the mice, and possibly in humans.

A release from Johns Hopkins quotes Paul Fuchs, Ph.D., the John E. Bordley Professor of Otolaryngology-Head and Neck Surgery at the Johns Hopkins University School of Medicine, as saying, “The nerve cells that connect to the sensory cells of the inner ear are known to inhibit hearing, and although it’s not yet clear whether that’s their function in older mice, it’s quite likely,” says “If confirmed, our findings give us new ideas for how physicians may someday treat or prevent age-related hearing loss.”

Fuchs says the new research builds on the knowledge that inside the ear lies a coiled row of sensory cells responsible for converting sound waves into electrical signals sent through nerve cells to the brain, which processes and tells animals what they “hear.” Two sets of these so-called hair cells — named for the filaments that act like antennae picking up sound waves — exist, an inner tier closest to the brain and an outer tier. The outer ones have a secondary function: to amplify the sound waves within the inner ear. Not surprisingly, Fuchs notes, a loss of outer hair cells closely correlates with a loss of hearing.

But studies over the last decade have suggested that changes over time also occur in the connections between hair cells and the nerve cells to which they are attached.

Each of those nerve cells is like a one-way street, Fuchs says, taking signals either from the ear to the brain or vice versa. The nerve cells that take signals to the ear are known to turn down the amplification provided by outer hair cells when an animal is, for example, exposed to a noisy environment for an extended period of time.

Previous research has suggested that with age, inner hair cells in mice and humans experience a decrease in outgoing nerve cell connections, while incoming nerve cell connections increase.

To find out if the new connections worked — or worked normally — Stephen Zachary, a graduate student in Fuchs’ laboratory, painstakingly recorded electrical signals from within the inner hair cells of young and old mice.


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