low testosterone file
Low Testosterone + Sex Drive
Men's Health
Prostate cancer

Low T? No Worries! Therapy Won’t Raise the Risk of Prostate Cancer.

Men with low levels of the male sex hormone testosterone need not fear that testosterone replacement therapy will increase their risk of prostate cancer.

This is the finding of an analysis of more than a quarter-million medical records of mostly white men in Sweden. The research was led by investigators at New York University Langone Medical Center and its Laura and Isaac Perlmutter Cancer Center. The international team of study authors will presented their results on May 9th 2016 at the annual meeting of the American Urological Association in San Diego, California.

A release from NYU notes that In the study, researchers found that as a group, men prescribed testosterone for longer than a year had no overall increase in risk of prostate cancer and in fact had their risk of aggressive disease reduced by 50 percent.

The release quotes lead study investigator and NYU Langone urologist Stacy Loeb, MD, MSc. As saying, “Based on our findings, physicians should still be watching for prostate cancer risk factors — such as being over the age of 40, having African-American ancestry, or having a family history of the disease — in men taking testosterone therapy, but should not hesitate to prescribe it to appropriate patients for fear of increasing prostate cancer risk.”

Loeb points out that much of the concern over cancer risk is that, as part of standard therapy for advanced prostate cancer, tumor growth is decreased by drugs that drastically reduce rather than increase male hormones. “But when used appropriately by men with age-related low testosterone who are otherwise healthy, testosterone replacement has been shown to improve sexual function and mood.”

The researchers say use of testosterone therapy — taken by mouth, gel patch, or injection to treat “low T” — has skyrocketed in the past decade. Its popularity is a consequence, experts say, of an aging “boomer” population and heavy drug industry marketing, and has come about despite its unknown, long-term health risks. According to some surveys, use of testosterone therapy has more than tripled since 2001, with more than 2 percent of American men in their 40s and nearly 4 percent of men in their 60s taking it. Testosterone levels drop naturally by about 1 percent per year in men past their 30s.

Specifically, the current study found that 38,570 of the men whose records were examined developed prostate cancer between 2009 and 2012. Of these men, 284 had prescriptions for testosterone replacement therapy before they were diagnosed with prostate cancer. Their records were compared with 192,838 men who did not develop prostate cancer, of whom 1,378 had used testosterone therapy.

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