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New Superfoods to Tackle Heart Disease & Diabetes

A new generation of superfoods that tackle heart disease and diabetes could be developed following research into a protein that helps keep cells in our bodies healthy, according to researchers at the University of Warwick Medical School in the UK. The team found that the protein, called Nrf2, continually moves in and out of the nuclei of human cells to sense the cell’s health and vitality. The study was published in September 2014 in Antioxidants and Redox Signalling.

A release from the university explains that when Nrf2 is exposed to threats to the cell’s health, it oscillates faster and activates an increase in the cell’s defense mechanism, including raising the levels of antioxidant.

The researchers successfully increased the speed of Nrf2’s movement by artificially introducing health beneficial substances – potential components of new superfoods.

The beneficial substances comprise broccoli-derived sulforaphane as well as quercetin, which is found in high-levels in onions.

The team used these insights to develop new food supplements, which are currently being trialled to decrease risk of developing diabetes and heart disease. The research investigated the ways in which compounds in fruit and vegetables keep humans healthy.

The team is the first to record the continual movement cycle of Nrf2, which sees the protein oscillate in and out of the cell nucleus once every 129 minutes. When stimulated by a health beneficial vegetable-derived substance, Nrf2’s cycle sped up to 80 minutes.

The release quotes lead researcher Professor Paul Thornalley as saying, “The way Nrf2 works is very similar to sensors in electronic devices that rely on continual reassessment of their surroundings to provide an appropriate response. The health benefit of Nrf2 oscillating at a fast speed is that surveillance of cell health is increased when most needed, that is, when cells are under threat. By understanding how this process works and increasing Nrf2’s speed without putting cells under threat, new strategies for design of healthier foods and improved drugs can be devised. Current designs may have selected substances with suboptimal if not poor health benefits in some cases.”

Commenting on the research, Professor Andreu Palou, coordinator of the EU-funded BIOCLAIMS research program, said “A main nutritional challenge in Europe is to substantiate the beneficial effects of foods that are advertised to the consumers. The approach of the group of Prof Thornalley is opening a fascinating new window.”

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