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Protecting Healthy Gut Microbes from Antibiotics

Gut microbes promote human health by fighting off pathogens, but they also contribute to diseases such as diabetes and cancer. A study published March 19th 2015 by Cell Reports reveals a potential strategy for tipping the balance in favor of good bacteria by altering the composition of the microbial community.

A release from the publisher reports that a group of Portuguese and Spanish researchers found that a chemical signal called autoinducer-2 (AI-2), which bacteria use to communicate with each other, can promote the right balance of gut microbes in antibiotic-treated mice. The findings pave the way for therapeutic strategies that harness the chemical language of bacteria to foster a healthy community of gut microbes.

The release quotes senior study author Karina de Bivar Xavier of the Instituto Gulbenkian de Ciência in Portugal as saying, “The bacteria in our intestines are extremely important for many aspects of our health. If we learn how to tailor their species composition and their functions in our favor, we will be able to use these bacteria to prevent infections and develop treatments for inflammatory bowel diseases and diet-induced microbial imbalances.”

Antibiotic use and dietary factors can change the composition of gut microbes and strongly reduce bacterial diversity, posing a serious threat to human health by increasing host susceptibility to harmful pathogens such as Salmonella. In particular, shifts in the balance between Bacteroidetes and Firmicutes–the two predominant phyla in the mammalian gut–are associated with obesity, diabetes, chronic inflammatory bowel diseases, and gastrointestinal cancer. The ability to drive this community from a disease state to a healthy state, by manipulating the native signals and interactions that occur between its members, offers great potential for therapeutic benefit.

To test this idea, Xavier and her team focused on a small diffusible molecule called AI-2, which fosters interspecies communication throughout the bacterial kingdom. AI-2 produced by one species can influence gene expression in another species, enabling the entire population to synchronously regulate behaviors such as virulence and biofilm formation. These features make AI-2 an excellent candidate for mediating cell-cell interactions in the mammalian gut, where hundreds of bacterial species co-exist and interact.

To manipulate AI-2 levels in the mouse gut, the researchers constructed an Escherichia coli mutant that was deficient at absorbing AI-2 from the environment. When this mutant was introduced into the gastrointestinal tract of mice that were being treated with an antibiotic, the resulting increase in intestinal AI-2 levels altered the composition of gut microbes to favor the expansion of the Firmicutes phylum, which had been almost eliminated by the antibiotic.

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