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Regulator of Amyloid Plaque Buildup in AD

Scientists from the Florida campus of The Scripps Research Institute have identified a critical regulator of a molecule deeply involved in the progression of Alzheimer’s disease.

The new study, published in an advance online edition of the Journal of Biological Chemistry, shows for the first time that levels of this regulating protein are decreased in the brains of Alzheimer’s disease sufferers and that this decrease could be a significant factor in the advance of the disease.

The regulator is known as Rheb, a protein that many believe may be active in neural plasticity, the ability of the brain to change in response to learning. The Scripps scientists found that Rheb binds and regulates activity of a molecule known as BACE1, an important enzyme in Alzheimer’s disease pathology, establishing for the first time a new molecular link between Rheb and BACE1.

A release from the institute quotes lead researcher Srini Subramaniam as saying, “We found that Rheb regulates BACE1, which is a major drug target in Alzheimer’s disease. Studies of the autopsied brains of Alzheimer’s patients have found a significant reduction in Rheb, so it is possible that an increase in Rheb could reverse the buildup of amyloid plaque.”

The study noted that in some genetically modified animal models, an increase of Rheb has already been shown to reduce BACE1 levels and the production of amyloid plaque.

“If we can uncover the mechanism by which Rheb alters BACE1 levels, that would be a very good drug target,” said Neelam Shahani, a first author of the study with William Pryor.  

“We’re very interested in the disease process and plan to keep moving forward to understand precisely how Rheb regulates BACE1,” said Pryor.

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