genetics
Medical Research

Removing Race from Human Genetic Research

A group of scientists is urging colleagues to take a step forward and stop using racial categories when researching and studying human genetics.

According to a February 2016 release from Drexel University in Philadelphia, the opening passage of a paper published in Science, written by Drexel School of Public Health’s Michael Yudell, the University of Pennsylvania’s Dorothy Roberts and Sarah Tishkoff, and the American Museum of Natural History’s Robert DeSalle, the team says “It is time for biologists to find a better way,”

Yudell and his co-authors point to evidence from phylogenetics and population genetics “that racial classifications do not makes sense in terms of genetics.” When applying simple biological methods, the co-authors contend that commonly defined racial groups “lack clear-cut genetic boundaries.”

One clear problem with using race as a distinguishing factor in modern biology and medicine is that “racial assumptions are not the biological guideposts some believe them to be,” the co-authors said. Furthermore, they point to how the continued use of race in genetic studies has fueled racist beliefs, so much so that leading biologists were forced, in 2014, to refute claims about “the genetic basis of social differences between races.”

It’s also important to not confuse ancestry with the concept of race, the co-authors point out.

“Ancestry is a statement about an individual’s relationship to other individuals in their genealogical history; thus, it is a very personal understanding of one’s genomic heritage,” they said. “Race, on the other hand, is a pattern-based concept that has led scientists and laypersons alike to draw conclusions about hierarchical organization of humans.”

As such, the team of experts believes that race should be phased out from genetic research and more deliberate language like “ancestry or population” used to describe the grouping for studies. Those terms should also be “clearly define[d].”

“Language matters, and the scientific language of race has a significant influence on how the public (which includes scientists) understands human diversity,” the co-authors wrote. “Having journals rationalize the use of classificatory terminology in studying human genetic diversity would force scientists to clarify their use and allow researchers to understand and interpret data across studies.”

Such an effort would allow for less confusion across studies and also “send out an important message to scientists and the public alike: historical racial categories that are treated as natural and infused with notions of superiority and inferiority have no place in biology.”

That’s not to say that race as a construct has no value at all when it comes to scientific study. Yudell and his co-authors agree that, although it contains it’s own set of issues, race can be used as a social and political category to better understand inequities and the health disparities therein.

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