The Irritable Male Syndrome And Male Menopause By blog "He used to be the nicest guy you could imagine, now he's become moody and mean." I hear this bewildered concern from women all over the world. "She used to be gentle and caring, now she treats me like her worst enemy. Men are equally frustrated and confused. Millions of women and men are finding that something strange is happening to them when their relationship moves into mid-life.