Mental & Emotional Health

Positive Memories May Cure Stress-Induced Depression

Artificial reactivation of positive memories can suppress the effects of depression induced by stress, according to scientists at the RIKEN-MIT Center for Neural Circuit Genetics, a joint collaboration of RIKEN Brain Science Institute in Japan and MIT.

The research, published in the journal Nature, shows how positive and negative memories interact in mood disorders, and provides a specific brain circuit for future clinical interventions.

According to a news release from RIKEN, the investigation was conducted in the laboratory of RIKEN Brain Science Institute Director Susumu Tonegawa, an MIT Professor and 1987 Nobel Laureate for the discovery of antibody diversity.

To answer the question of whether a positive memory can overwrite a negative one, the researchers used genetic engineering to create mice in which memory cells from a brain area called the dentate gyrus (DG) could be tagged while memories formed, and later reactivated with a blue light-emitting optical fiber implanted in the DG. The team could then turn on memory cells created during previous experiences.

In the test of the system, male mice were given a positive experience—exposure to a female mouse—and formed a memory of the event. They were then exposed to a stressful experience that led to a depression-like state. While they were depressed, light was used to stimulate the DG of some mice and reactivate the memory cells for the positive experience. Surprisingly, this resulted in a robust recovery from the depressed state. Mapping the brain circuit for this effect revealed two other brain areas—the BLA and NAcc—that cooperate with the DG.

To examine whether this type of recovery from depression can include persistent changes in brain circuitry, the researchers supplied chronic light therapy to the DG over 5 days, ensuring sustained reactivation of the positive memories. Mice who received this therapy were resilient to the negative effects of stress-induced depression, suggesting that memory storage of positive experiences in the DG can be used to suppress the damaging effects of stress.

The authors say it is too early to conclude whether positive memories in general can mitigate the effects of stressful depression. However, it is clear that DG cells are promising targets for therapeutic approaches to maladaptive mood states.


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