Some Cancers Respond to Anti-Inflammatory Drugs

Research done at the Washington University School of Medicine in St. Louis raises the possibility that some cancer patients with aggressive tumors may benefit from a class of anti-inflammatory drugs used to treat rheumatoid arthritis. The investigators published their findings in a 2014 issue of the journal Cell Reports.

Many Elderly BC Patients Are Taking Hormone Therapy

Women over 65 with non-metastatic breast cancer are likely to follow recommendations for preventive hormone treatment. But non-white women were much less likely to have that therapy.

The women who had the therapy suffered from estrogen-positive breast cancer and were given either an aromatase inhibitor or tamoxifen. Those hormones prevent tumors from using estrogen to fuel growth.

The study was reported in the Journal of Clinical Oncology.

A Possible Link Between Carbohydrates and Breast Cancer

Limiting carbohydrate intake could reduce the risk of one type of breast cancer, researchers have found.

The findings, published in the journal Cancer Epidemiology Biomarkers & Prevention, focused on the cancer whose tumor tissue has the IGF-1 receptor.

“There is a growing body of research demonstrating associations between obesity, diabetes, and cancer risk,” said lead author Jennifer A. Emond, an instructor in the Department of Community and Family Medicine at the Geisel School of Medicine at Dartmouth College.

Breast Cancer and Malfunctioning Cells in Older Women

Scientists are a step closer to understanding why older women are more susceptible to breast cancer.

Researchers from the Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab) said their study shows that as women age, cells that that are responsible for maintaining healthy breast stop responding to cues that should prompt them to suppress nearby tumors.

According to the National Cancer Institute, breast cancer is most frequently diagnosed among women aged 55 to 64.

Chemotherapy and Hospitalization

Scientists have zeroed in on which chemotherapy regiments are likelier to lead to hospitalizations for early stage breast cancer patients.

The retrospective study, published in the Journal of Clinical Oncology, was conducted by researchers from the University of Texas MD Anderson Cancer Center. For their analysis, the researchers looked at hospitalization-related insurance claims by patients who were undergoing varying chemotherapy regimens.

Double Mastectomy Doesn’t Increase Survival

Many women diagnosed with cancer in one breast undergo a contralateral prophylactic mastectomy (CPM) to remove both breasts. Yet removing the unaffected breast has not been shown to increase survival, according to a study done at the University of Michigan and published online May 21st 2014 in Jama Surgery.

Hope for Beating HER2-Positive Breast Cancer

Scientists at Cold Spring Harbor Laboratory on Lonf Island in New York report on May 18th 2014 a discovery that they hope will lead to the development of a powerful new way of treating an aggressive form of breast cancer commonly called “HER2-positive”.

Misguided Fear of Radiation from Mammograms

Misinformation and misunderstanding about the risks associated with ionizing radiation have created heightened public concern and fear that may result in women avoiding mammograms that can detect early cancers, according to the American Roentgen Ray Society(ARRS), a radiology society was founded in 1900 in Leesburg, VA.

Sleeping Well Boosts Survival for Breast Ca Patients

A study done at Stanford and published in the May 1st 2014 issue of the journal Sleep reports that “sleep efficiency”, defined as the ratio of time asleep to time spent in bed, is predictor of survival time for women with advanced breast cancer.

Chemo for Breast Ca May Lead to Job Loss

A study done at the University of Michigan Health System has found that loss of paid employment after a diagnosis of early-stage breast cancer may be common and potentially related to the type of treatment patients received. Published early online in Cancer, a peer-reviewed journal of the American Cancer Society, the findings support efforts to reduce the side effects and burden of treatments for breast cancer and to identify patients who may forego certain treatments, particularly when the expected benefit is low.

Study: Chemotherapy Not Always Best for Breast Cancer

Although many women with early-stage breast cancer are getting chemotherapy, the ones that decide against it appear to be more empowered about making a good decision, new research indicates.

The current guidelines for treating cancer that hasn’t spread to the lymph nodes or other parts of the body have led to thousands of women receiving chemotherapy without benefiting from it.

Doubling “Progression-Free Survival” of Breast Ca Patients

The amount of time patients with hormone-receptor–positive breast cancer were on treatment without their cancer worsening, which is called "progression-free survival", was effectively doubled in women with advanced breast cancer who took the experimental drug palbociclib. That was the result of the final clinical trials conducted by researchers from the Revlon/UCLA Women's Cancer Research Program at Jonsson Comprehensive Cancer Center on the campus of the University of California, Los Angeles.

Hope For Treating A Deadly Breast-Cancer Gene

Researchers have discovered that a gene, previously not linked to breast cancer, plays a central role in the growth of triple negative breast cancer.

Targeting that gene, the research indicates, could lead to a new approach for treating that form of the disease.  Triple negative breast cancer, which accounts for 20 percent of all breast cancer cases, often has few treatment options.

Breast Reconstruction: Making the Decision

Every woman who has a mastectomy is then faced with another choice: whether to have breast reconstruction – surgery to rebuild the shape of the breast. There are other choices, according to the National Cancer Institute (NCI): to wear a breast form, or padding, or to do nothing.

Mammogram Risks for Age 70+ Outweigh Benefits

Researchers from Leiden University Medical Centre in The Netherlands report that their study suggests that breast cancer screening programs for older women results in a large proportion of women being over-treated, and at risk from the harmful effects of such treatment, because these women were more likely to die from other causes than from any tumors detected in the early stages of growth. The team presented the findings the European Breast Cancer Conference in Glascow UK.

Subtyping Breast Ca to Identify High Risk Women

A University of South Florida-led study has refined a personalized approach to breast cancer diagnosis and treatment. A release from the university explains that a method called molecular subtyping can help doctors better determine which of their breast cancer patients are at high risk of getting breast cancer again. This sophisticated genetic profiling of an individual's specific tumor offers an additional resource to help identify patients who would most benefit from chemotherapy and those who would not.

Stopping Aggressive Breast Cancer

The chance of breast cancer spreading beyond the initial tumor may be decreased by lowering the level of a protein, according to new research.

A team of investigators from The Ohio State University found that mice implanted with breast cancer cells without the protein, myoferlin, developed self-contained tumors whose cells did not spread beyond the original site.

In contrast, mice implanted with cancer cells containing the protein developed larger, irregular masses and showed signs that cancer cells had invaded the surrounding tissue.