Menopause

Hormones and Hypertension

Women ages 45 years and older taking estrogen hormone therapy in pill form were more likely to develop high blood pressure than those using transdermal (topical, applied to the skin) or vaginal formulations, according to new research published today in June 2023 in Hypertension, a peer-reviewed American Heart Association journal.

A woman’s body produces less estrogen and progesterone after menopause, changes that may increase the risk for cardiovascular diseases including heart failure, according to the American Heart Association.

Hormone therapy may be prescribed to relieve symptoms of menopause, in gender-affirming care and in contraception, and previous studies have found that some hormone therapies may reduce cardiovascular disease risk in menopausal women under 60 years of age or for whom it has been fewer than 10 years since menopause. The authors of this study noted that while high blood pressure is a modifiable risk factor for cardiovascular disease, the potential effects of different types of hormone therapy on blood pressure in menopausal women remain uncertain.

“It’s really important to have greater knowledge on safe and effective hormonal treatments for women during menopause. At the end of the day, it’s an individualized decision about what is best for the person going through menopause and should include open dialogue with their physician or health care team,” Ahmed said. “We need large, randomized studies factoring in all the complexities of hormone therapy around this important transition period in the female lifecycle.”

“We know estrogens ingested orally are metabolized through the liver, and this is associated with an increase in factors that can lead to higher blood pressure,” said lead study author Cindy Kalenga, an M.D./Ph.D.-candidate at the University of Calgary in Alberta, Canada.

“We know that post-menopausal women have increased risk of high blood pressure when compared to pre-menopausal women. Fthermore, previous studies have shown that specific types of hormone therapy have been associated with higher rates of heart disease,” Kalenga said. “We chose to dive deeper into factors associated with hormone therapy, such as the route of administration (oral vs. non-oral) and type of estrogen, and how they may affect blood pressure.”

This study involved a large group of over 112,000 women, ages 45 years and older, who filled at least two consecutive prescriptions (a six-month cycle) for estrogen-only hormone therapy, as identified from health administrative data in Alberta, Canada between 2008 and 2019. The main outcome of high blood pressure (hypertension) was identified via health records.T

First, researchers investigated the relationship between route of estrogen-only hormone therapy administration and risk of developing high blood pressure at least one year after starting the treatment. The 3 different routes of hormone therapy administration were oral (by mouth), transdermal and vaginal application. Additionally, researchers evaluated the formulation of estrogen used and the risk of developing high blood pressure. For this study, the researchers reviewed medical records of individuals taking estrogen-only hormone therapy. The two most common forms of estrogen used by study participants were estradiol — a synthetic form of estrogen that most closely mimics what is naturally produced in women’s bodies in the premenopausal years — and conjugated equine estrogen, an animal-derived form of estrogen and the oldest type of estrogen therapy.

The analysis found:

Women taking oral estrogen therapy had a 14% higher risk of developing high blood pressure compared to those using transdermal estrogen and a 19% higher risk of developing high blood pressure compared to those using vaginal estrogen creams or suppositories.

After accounting for age, a stronger association was seen among women younger than 70 years of age compared to women older than 70.

Compared to estradiol, conjugated equine estrogen was associated with an 8% increased risk of developing high blood pressure.

Taking estrogen for a longer period of time or taking a higher dose was associated with greater risk of high blood pressure, the authors noted. According to Kalenga, the study’s findings suggest that if menopausal woman take hormone therapy, there are different types of estrogen that may have lower cardiovascular risks.

“These may include low-dose, non-oral estrogen — like estradiol, in transdermal or vaginal forms — for the shortest possible time period, based on individual symptoms and the risk–benefit ratio, Kalenga said. “These may also be associated with the lowest risk of hypertension. Of course, this must be balanced with the important benefits of hormone therapy, which include treatment of common menopausal symptoms.”

The average age of natural menopause among women worldwide is about 50 years of age. Current evidence supports that initiating menopausal hormone therapy in the early stages may have cardiovascular benefits, though not in the late stages of menopause, according to the American Heart Association’s 2020 Statement on Menopause Transition and Cardiovascular Disease Risk: Implications for Timing of Early Prevention. Previous studies have found that menopausal hormone therapy may help relieve symptoms of menopause, including hot flashes, night sweats, mood changes or sleep disturbances.

“Over a quarter of the world’s population of women are currently older than the age of 50. By 2025, it’s estimated that there will be one billion menopausal individuals on the planet,” said study co-author Sofia B. Ahmed, M.D., M.M.Sc., a professor of medicine at the University of Calgary, Alberta, Canada. “Approximately 80% of people going through menopause have symptoms, and for some it lasts up to seven years. While menopause is a normal part of the aging process, it has huge implications for quality of life, economic impact, work productivity and social relationships. We need to give people the information they need to choose the most effective and safe hormonal treatments for menopause.”

The study had several limitations. The impact of different forms of hormone therapy on high blood pressure outcomes were based only on medical records. The study did not include women younger than the age of 45 and did not collect data about hysterectomies or menopausal status; however, the researchers used initiation of estrogen therapy in women over the age of 45 to indicate postmenopausal status. The researchers included estrogen-only therapy in this study, which is most often prescribed for women who have had a hysterectomy (surgical removal of the uterus), whereas women with an intact uterus may receive a combination of estrogen and progestin, another type of hormone. This means these findings may only be considered for women taking estrogen-only hormone therapy, the authors noted. Additionally, the study’s findings cannot offer definitive insights on other populations who may benefit from estrogen hormone therapy, including women who have an intact uterus or women who experience premature or early menopause.

The research study reviewed women in Canada, which may present differences. However, current guidelines in Canada align with U.S. guidelines from the American College of Obstetricians and Gynecologists. Both recommend the use of hormone therapy in women with appropriate indications and note that hormone therapy should not be considered as prevention or treatment of hypertension or heart disease.

you may also like

Recipes We

Khela88

Fancywin

Jita Ace

Betjili

https://betvisa1.org/

jeetbuzz লগইন

jeetwin app

baji999

winbuzz

betvisa login

winbuzz

six6s

babu88

marvelbet

krikya

mostplay

4rabet

leonbet

pin up

mostbet

all rummy app

Fastwin

Jitawin

R777

Bhaggo

PBC88

Winbdt

Crickex

Betjee

Glory Casino

Jita Bet

Melbet

Jwin7

Jita Ace

Krikya

Six6s

Betjili

Mostplay

Jeetbuzz

Jeetwin

Mostbet

Baji999

Marvelbet

Betvisa

Mcw

Nagad88

Babu88

Jaya9

babu88 babu88 jeetwin abbabet nagad88 marvelbet melbet mostbet six6s crickex mcw casino baji999 betvisa krikya mostplay crazy time jeetbuzz 79king1 good88 11bet xoso66 nohu78 xin88 nohu90 v9bet fastwin betvisa
jeetbuzz
babu88
babu888
jeetwin
nagad88
jaya9
khela88
mostplay
baji999
abbabet
1xbet 12bet marvel bet 91 club betvisa login baji999 sky247 gugobet lotus365 yolo247 bsport loto188 bsport site 8day xoso66 v9bet rummy deity yono rummy new88 typhu88 jeetbuzz dafabet lotus365 bet88 v9bet đăng nhập thienhabet 188bet link dafabet login betvisa king567 yolo247 login 1xbet login 24betting 91club crickex kubet new88 hi88 jun88 w88 shbet mksports 33win f8bet 123b fb88 vn88 mu88 five88 bk8 w388 gnbet mcw casino thienhabet sodo casino cmd368 bsport eubet sbobet mibet cmd368 Faridabad Satta Satta King 786 Dafabet betvisa yono rummy rummy apk

alo789

https://metalwave.com.mx/app/

https://meisetio.com/wp-includes/js/jquery/ai/index.php?tunnel=alo-789

https://purneauniversity.ac.in/assets/js/mk/?tunnel=baji999

fastwin

fastwin

winzo

winzo

futemax

Kèo nhà cái

bongdadzo

Tỷ số bóng đá

KQBD

Kết quả bóng đá

rummy nabob

hi88

8day

97win

n88

red88

king88

j88

i9bet

good88

nohu78

99ok

bet168

satta king

satta matta matka

Canais Play

ALO789

yono rummy
rummy deity
rummy nabob
rummy wealth
daman games
jeetbuzz
yolo247
baji999
rummy gold
188bet
v9bet
789bet
crickex
1xbet
thienhabet
c54
sky88
33win
79king
kubet
shbet
good88
3king
nohu
lucky88
97win
xoso66
xin88
daga88
yolo247
jeetbuzz
betvisa
jeetwin
baji999
nagad88
babu88
mostplay
babu888
jaya9
khela88
jaya9
khela88
jeetbuzz
betvisa
abbabet
babu88
babu888
jeetwin
nagad88
jaya9
joya 9
khela88
mostplay
marvelbet
baji999

Sponsored From Malaysia

말레이시아에서 후원