Can A Person Ever Be Fully Prepared to Care for Someone with Alzheimer's? By Jane Farrell blog Earlier this year, I attended a caregivers conference at the University of Minnesota. The morning keynote speaker was absolutely terrific ΓÇö an engaging, informed speaker who was also funny and self-deprecating.
Five Trials Are Targeting Alzheimer's By Jane Farrell blog Recently I noticed a tweet from TIME magazine about some new research trials focusing on AlzheimerΓÇÖs disease. Intrigued, I visited their website to learn more. The headline - ΓÇ£5 Groundbreaking Drugs are Testing Ways to Prevent AlzheimerΓÇÖs - is what caught my attention. I love the words ΓÇ£groundbreakingΓÇ¥ and ΓÇ£preventΓÇ¥ ΓÇö especially when they are used in connection with AlzheimerΓÇÖs disease or another type of dementia.
_ A New Kind of Drug for Alzheimer's? By Jane Farrell article Researchers have discovered a new drug target to fight AlzheimerΓÇÖs, and the finding could lead to a new diagnostic tool as well. Earlier drugs have long targeted the amyloid protein called plaques, which can cause neurons in the brain to die. But Penn State University researchers have found that another substance, a neurotransmitter known as GABA, could also be implicated in the development of AlzheimerΓÇÖs.
_ Depression LInked to Quicker Progression of Alzheimer's By Jane Farrell article Late-life depression could be a major risk factor for developing AlzheimerΓÇÖs more quickly than those who arenΓÇÖt depressed. The finding was presented at the annual meeting of the Society of Nuclear Medicine and Molecular Imaging. ΓÇ£Our results clearly indicate that mild cognitively impaired subjects with depressive symptoms suffer from elevated amyloid-levels when compared with non-depressed individuals,ΓÇ¥ said the studyΓÇÖs principal scientist Axel Rominger, MD, from the department of nuclear medicine at the University of Munich in Germany.
The "Alzheimer's Movie" By blog There are hundreds and hundreds of books on the topic of the AlzheimerΓÇÖs disease, the brain and brain health. But there are few novels that feature the disease as its central plot. One single novel stands out. ΓÇ£Still AliceΓÇ¥ is the best-selling book written by first-time author Lisa Genova, a Harvard-educated neuroscientist. Published in 2009, ΓÇ£Still AliceΓÇ¥ is a moving, compelling and heart-breaking work of fiction that totally captures the experience of early-onset AlzheimerΓÇÖs. If you have not read it, I highly recommend you do. This book will move you to tears.
_ The Hardest Part of Alzheimer's Caregiving By Jane Farrell article Everyone whoΓÇÖs cared for an AlzheimerΓÇÖs patient knows how sad and frustrating the changes can be. But perhaps among all the effects of the illness ΓÇô difficult communication; hallucinations; wandering; disturbed sleep patterns ΓÇô aggression, often accompanied by agitation, can be the most unsettling. Patients may get so angry that they literally lash out at others, occasionally even putting caregivers in harmΓÇÖs way.
_ A Step Forward In the Fight Against Alzheimer's By Jane Farrell article Researchers have developed a molecular compound that reversed the symptoms of AlzheimerΓÇÖs in mice. The compound also reduced inflammation of the brain. The compound, antisense oligonucleotide (OL-1), ΓÇ£reversed learning and memory deficits and brain inflammation in mice that are genetically engineered to model AlzheimerΓÇÖs disease,ΓÇ¥ said Susan Farr, Ph.D., research professor of geriatrics at Saint Louis University. The findings were published in the Journal of AlzheimerΓÇÖs Disease.
Antidepressant May Slow Alzheimer's By article Citalopram (brandname Celexa), a commonly prescribed antidepressant, can reduce production of the main ingredient in Alzheimer's brain plaques. That is the finding research done at Washington University School of Medicine in St. Louis and the University of Pennsylvania. The study was published May 14th 2014 in Science Translational Medicine.
_ Protein Fragments and Alzheimer's By Jane Farrell article Two newly discovered protein fragments may lead to drugs that will better treat Alzheimer’s disease. In a study published in the Journal of Alzheimer’s Disease, Prof. Illana Gozes, of Tel Aviv University’s Sagol School of Neuroscience, said that investigators had already focused on a protein called NAP, which is essential for brain formation. Now, they have found similar protein fragments. In their study, investigators looked at the effect of the fragments on mice with symptoms similar to thse of Alzheimer’s.
_ Alzheimer's Subtype Often Misdiagnosed By Jane Farrell article Neuroscientists have defined a subtype of Alzheimer’s disease (AD) that they say is neither well recognized nor treated appropriately. The variant - called hippocampal sparing AD - made up 11 percent of the 1,821 AD-confirmed brains examined by researchers from the Mayo Clinic in Florida.
Why Do More Women Develop Alzheimer's Disease? By blog Recently, I turned on the radio in my car and heard the last few minutes of an MPR [Minnesota Public Radio] All Things Considered segment about Alzheimer’s disease. A few days later I googled the subject matter and found this MPR link to the audio and an accompanying online story. Take a few minutes to read or listen to the broadcast.
Alzheimer's Disease and the Early-Onset Colombian Connection By blog I’m a huge fan of the CBS news show Sunday Morning. It’s 90 minutes of quality programming that I look forward to every week.
_ Can An Alzheimer's Protein Be Stopped? By Jane Farrell article Researchers have devised a new approach to the treatment of Alzheimer’s by identifying a class of compounds that can decrease a deadly protein associated with dementia. The compounds, called pharmacologic chaperones, can decrease levels of amyloid-beta. That protein is thought to contribute to the development of dementia. The mouse-model study, by researchers from Columbia University Medical Center (CUMC), Weill Cornell Medical College, and Brandeis University, was published in the journal Nature Chemical Biology.
_ The New Challenges of Alzheimer's By Jane Farrell article The growing incidence of Alzheimer’s raises many question beyond diagnosis and, eventually treatment. As a society, we also need to think about the ethical and policy choices we are faced with, an expert says.
_ Exercise For Alzheimer's Patients By Jane Farrell article Editor’s Note: Exercise has myriad benefits, and the same holds true for people with Alzheimer’s. In addition to mental exercise and social interaction, physical activity is essential. It can help keep muscles and the heart in shape, reduce stress and depression and maintain an even weight. The companionship it provides with visitors or caregivers can also be helpful. Here, from the National Institute on Aging’s Go4Life program, are some tips for caregivers to help their loved ones get into a physical routine, or maintain one:
An Alzheimer's Toolkit For Caregivers By blog If you’re caring for someone with dementia symptoms you’ll already be aware of the complex challenges it presents. People with Alzheimer’s or other forms of dementia are affected by a range of symptoms, including memory loss, difficulty communicating, changes in mood, agitation, depression, physical issues and so much more. These symptoms are not difficult just for the person who is ill, but for their loved ones as well. In fact, they can be overwhelming.
I Want To Take The Alzheimer's Test By blog Last night I had trouble getting to sleep. Tossing and turning, I attempted to clear my thoughts, but my brain had other ideas. My mind was on an instant replay loop: A new study reveals researchers have developed a blood test that will predict if a healthy person — someone with no symptoms — is likely to develop Alzheimer’s disease within the next few years. The study focused on people over 70 and was about 90 percent accurate.
_ Slowing Down Alzheimer's Plaques By article University of Michigan researchers have learned how to fix a cellular structure called the Golgi that mysteriously becomes fragmented in all Alzheimer's patients and appears to be a major cause of the disease. The scientists say that understanding this mechanism helps decode amyloid plaque formation in the brains of Alzheimer's patients—plaques that kills cells and contributes to memory loss and other Alzheimer's symptoms.