Sleep Health 7 Hidden Causes of Fatigue By Jane Farrell article From the Cleveland Clinic Fatigue can signal anemia, diabetes, hypothyroidism or hepatitis C. But once your doctor rules out major medical causes of fatigue, it’s time to consider hidden ones. “We look for the less obvious roots of fatigue — that’s our job,” says Tanya Edwards, MD, Medical Director of Cleveland Clinic’s Center for Integrative Medicine. Hidden causes include: 1. A junk food diet
_ Heart Health New Heart Tx as Good as Gold Standard By article LCZ696, a drug with two antihypertensives to lower blood pressure, won a head to head comparison with ACE inhibitors, the gold standard treatment. The trial, which was conducted in Athens and called the PARADIGM-HF, was stopped abruptly in May 2014 because of a benefit to patients that was overwhelmingly statistically significant.
_ Clot-Busting Can Help or Harm Stroke Patients By article Johns Hopkins researchers say they have developed a technique that can predict with 95 percent accuracy which stroke victims will benefit from intravenous, clot-busting drugs and which will suffer dangerous and potentially lethal bleeding in the brain. Reporting online May 15th 2014 in the journal Stroke, the Johns Hopkins team says these predictions were made possible by applying a new method they developed that uses standard magnetic resonance imaging (MRI) scans to measures damage to the blood-brain barrier that protects the brain from drug exposure.
_ 10 Common Cancer Treatment Myths By Jane Farrell article By Mayo Clinic Staff As advances in the treatment of cancer have increased, you may have discovered more opportunities to learn the facts about this disease. Yet some misleading ideas about cancer treatment still persist. Timothy J. Moynihan, M.D., a cancer specialist at Mayo Clinic, Rochester, Minn., helps debunk some of the most common misconceptions about cancer treatment and explains the truth. Myth: A positive attitude is all you need to beat cancer.
Heart Health Viagra for Heart Failure? Works Better for the Guys By article Clear-cut gender differences stand out in measuring impact of Viagra as therapy for heart failure, according to a study done at Johns Hopkins and posted online May 16th 2014 in The Journal of Clinical Investigation. Specifically, in female mice modeling human heart failure, the benefits of sildenafil, the generic name for Viagra, ranged from robust to practically nonexistent depending on the animals' levels of the hormone estrogen. Yet in male mice, sildenafil generally appears to work well because it targets a different biological process independent of estrogen.
_ New Tx to Protect Brain Cells in PD By article April was Parkinson's Awarness Month, but here at ThirdAge we want to promote PD awarness all year long. To that end, here's a fascintating and encouraging new study about PD.
Antidepressant May Slow Alzheimer's By article Citalopram (brandname Celexa), a commonly prescribed antidepressant, can reduce production of the main ingredient in Alzheimer's brain plaques. That is the finding research done at Washington University School of Medicine in St. Louis and the University of Pennsylvania. The study was published May 14th 2014 in Science Translational Medicine.
_ Protein Fragments and Alzheimer's By Jane Farrell article Two newly discovered protein fragments may lead to drugs that will better treat Alzheimer’s disease. In a study published in the Journal of Alzheimer’s Disease, Prof. Illana Gozes, of Tel Aviv University’s Sagol School of Neuroscience, said that investigators had already focused on a protein called NAP, which is essential for brain formation. Now, they have found similar protein fragments. In their study, investigators looked at the effect of the fragments on mice with symptoms similar to thse of Alzheimer’s.
_ Stem Cells Make ΓÇ£Heart Disease-on-a-ChipΓÇ¥ By Jane Farrell article Harvard scientists have merged stem cell and “organ-on-a-chip” technologies to grow, for the first time, functioning human heart tissue carrying an inherited cardiovascular disease. The research appears to be a big step forward for personalized medicine because it is working proof that a chunk of tissue containing a patient's specific genetic disorder can be replicated in the laboratory.
Promise of New Meds for Allergies By article Help for sneezy, wheezy, itchy seasonal allergies may be at hand. Researchers at the University of Eastern Finland and Kuopio University Hospital, also in Finland, have identified several target molecules that are suitable for the development of new allergy drugs. The work, completed in a large-scale European Union project, was published in May 2014 in Journal of Allergy and Clinical Immunology.
Vision Health Plugging Blood Vessels to Save Vision By article The growth of malformed blood vessels that can burst is a leading cause of vision loss in North America. Retinopathy and retina degeneration are associated with premature birth, with diabetes, and with increasing age. Now a new drug approach has been developed by a research team led by Dr. Andras Nagy at the Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital in Toronto for safer clean-up of deformed blood vessels in the eye. The study was published in May 2014 in EMBO Molecular Medicine.
_ A Molecule That Could Battle Breast Cancer By Jane Farrell article Researchers have developed a new technique that uses a so-called “energy molecule” to trigger the release of anti-cancer drugs directly into cancer cells. It may be especially effective in breast cancer treatment. The findings were published in the journal Nature Communications. Once inside the cancer cells, the molecule, adenosine-5’-triphosphate (ATP), releases its “payload”: a collection of molecules embed with an anti-cancer drug called doxorubicin, which targets the nucleus of the cancer cell.
_ AFib = Dementia Risk If Meds Are Out of Range By article A study done by researchers at the Intermountain Medical Center Heart Institute in Salt Lake City has found that atrial fibrillation patients who are on blood thinning medications are at higher risk of developing dementia if their doses are not in the optimal recommended range. The findings presented at the 2014 Annual Heart Rhythm Society Scientific Session on Friday, May 9th, 2014 in San Francisco.
_ Living Well With Hepatitis C By Jane Farrell article By Jane Farrell Hepatitis C, an inflammation of the liver caused by a virus, is a discouraging, debilitating condition. It affects an estimated 3.2 million Americans, according to the federal Centers for Disease Control (CDC). The illness is usually caused by receiving donated blood that is infected, having had a bad organ transplant, or sharing a needle or having sex with a person who is contaminated with the virus.
_ New Cancer Tx Raises Blood Pressure By article The upside of new cancer therapies that block vascular endothelial growth factor (VEGF) signaling is that these agents have improved the outlook for patients with some cancers and are now used as a first line therapy for some tumors. However the downside is that almost 100% of patients who take VEGF inhibitors (VEGFIs) develop high blood pressure, and a subset develops severe hypertension. That is the finding of a study done at the Institute of Cardiovascular and Medical Sciences, University of Glasgow.
Caring for Horses Can Help Dementia Symptoms By Jane Farrell article Spending time with horses eases dementia symptoms for Alzheimer’s patients, according to the first study of its kind. The research, a collaboration between The Ohio State University and an adult daycare center, revealed that patients could groom, feed and walk horses under supervision. That experience improved patients’ mood and made them less likely to resist care or become upset later in the day.
_ Medical Care The Right Questions to Ask Your Doctor About Hepatitis C By Sondra Forsyth article By Sondra Forsyth The Centers for Disease Control has designated May as Hepatitis Awareness Month. One goal of that campaign is to let Boomers know that of the more than three million Americans infected with hepatitis C, over 75% are in their 50s and 60s. You can find out the extent of your risk with this 5-minute online assessment from the CDC.